Occasionally, minocycline therapy may result in autoimmune disorders such as drug-related lupus and autoimmune hepatitis, which usually occurs in men who also developed minocycline-induced lupus however, women are more likely to develop minocycline-induced lupus. Rare but serious side effects include fever, yellowing of the eyes or skin, stomach pain, sore throat, vision changes, and mental changes, including depersonalization. Permanent blue discoloration of gums or teeth discoloration may also occur.
SHELF LIFE OF DOXYCYCLINE SKIN
This staining is not permanent, but can take a very long time for the skin color to return to normal however, a muddy brown skin color in sun-exposed areas is usually permanent. Prolonged use of minocycline can lead to blue-gray staining of skin, fingernails, and scar tissue. It has also been linked to cases of lupus.
It increases sensitivity to sunlight, and may affect the quality of sleep and rarely causes sleep disorders. Minocycline may cause upset stomach, diarrhea, dizziness, unsteadiness, drowsiness, mouth sores, headache, and vomiting. See also: List of dental abnormalities associated with cutaneous conditions It is also contraindicated in people with severe liver impairment and after the 16th week of pregnancy. The drug is contraindicated in people with known hypersensitivity to tetracycline antibiotics, as there is complete cross sensitivity in this group. Recent research indicate that centrally infused minocycline attenuates brain microglial activation, neuroinflammation and sympathetic activation during pulmonary hypertension Contraindications However, the 2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis does not include minocycline. Minocycline and doxycycline have modest effectiveness in treating rheumatoid arthritis. Urinary tract infections, rectal infections, and infections of the cervix caused by certain microbesīoth minocycline and doxycycline have shown effectiveness in asthma due to immune-suppressing effects.Syphilis (when penicillin cannot be given).Respiratory infections such as pneumonia.Gougerot-Carteaud syndrome ( confluent and reticulated papillomatosis).Gonorrhea (when penicillin cannot be given).aureus infection and a disease caused by drug-resistant Acinetobacter spp. It may be used to treat certain strains of methicillin-resistant S. Īlthough minocycline's broader spectrum of activity, compared with other members of the group, includes activity against Neisseria meningitidis, its use for prophylaxis is no longer recommended because of side effects (dizziness and vertigo). Minocycline is also used for other skin infections such as methicillin-resistant Staphylococcus aureus. In order to reduce resistance rates as well as increase the effectiveness of treatment, oral antibiotics should be generally combined with topical acne creams such as benzoyl peroxide or a retinoid ( tretinoin, adapalene, etc.). In Europe and North America, a number of people with acne no longer respond well to treatment with tetracycline family antibiotics because their acne symptoms are caused by bacteria (primarily Cutibacterium acnes) that are resistant to these antibiotics. However, acne that is caused by antibiotic-resistant bacteria is a growing problem in many countries. Historically, minocycline has been an effective treatment for acne vulgaris. Both of these closely related antibiotics have similar levels of efficacy, although doxycycline has a slightly lower risk of adverse side effects. Minocycline and doxycycline are frequently used for the treatment of acne vulgaris. In the United States, minocycline is indicated to treat inflammatory lesions of non-nodular moderate to severe acne vulgaris in people nine years of age and older. Medical uses Minocycline 100-mg capsules manufactured by Ranbaxy Pharmaceuticals Acne In 2020, it was the 236th most commonly prescribed medication in the United States, with more than 1 million prescriptions. Minocycline was patented in 1961 and came into commercial use in 1971. It works by decreasing a bacterium's ability to make protein thus stopping its growth. Use in the later part of pregnancy may harm the baby and safety during breastfeeding is unclear. Serious side effects may include anaphylaxis, a lupus-like syndrome, and easy sunburning. Ĭommon side effects include nausea, diarrhea, dizziness, allergic reactions, and kidney problems. It is taken by mouth or applied to the skin. Minocycline is also used for the treatment of acne and rheumatoid arthritis. It is generally (but not always) less preferred than the tetracycline doxycycline. Minocycline, sold under the brand name Minocin among others, is a tetracycline antibiotic medication used to treat a number of bacterial infections such as pneumonia.
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